HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropylamine → O-Demethylmetoprolol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropylamine | HCID 6363 | — |
| Reactant | 2-{4-[(Oxiran-2-yl)methoxy]phenyl}ethan-1-ol | HCID 10420145 | — |
| Product | O-Demethylmetoprolol | HCID 162181 | — |
Reaction Steps
10 g of 1-[4-(2-hydroxyethyl)phenoxy]-2,3-epoxypropane produced in Example 1 was refluxed in 50 mL of isopropylamine for 16 hrs. The amine was removed under reduced pressure, the residue dissolved in warm toluene and the toluene removed under reduced pressure. On standing the oil solidified. Yield=12.8 g (98%). After recrystallization in petroleum ether this solid had a melting point of 77°-78° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04760182 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-0b9a455e6ea34a9e9a13f0b13d1cd086 |
| Source note | uspto-grants-1988_07 |