HCID 86600365, compound → HCID 131715651, compound

HRID 845895Notes

Reaction equation

HRID 845895 reaction equation
[CH3:1][N:2](C(OC(C)(C)C)=O)[C@H:3]([C:14]([NH:16][C@@H:17]([C:19]([N-:21][CH2:22][CH2:23][CH2:24][C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=1)=[O:20])[CH3:18])=[O:15])[CH2:4][C:5]1[C:10]([CH3:11])=[CH:9][C:8]([OH:12])=[CH:7][C:6]=1[CH3:13].[ClH:38].CO.O1CCOCC1>CO>[ClH:38].[CH3:1][NH:2][C@H:3]([C:14]([NH:16][C@@H:17]([C:19]([NH:21][CH2:22][CH2:23][CH2:24][C:25]1[CH:26]=[CH:27][CH:28]=[CH:29][CH:30]=1)=[O:20])[CH3:18])=[O:15])[CH2:4][C:5]1[C:6]([CH3:13])=[CH:7][C:8]([OH:12])=[CH:9][C:10]=1[CH3:11]

Participants

4

Reactant 2

HCID 86600365HCID 86600365, compoundHCID 178429005HCID 178429005, compound

Product 1

HCID 131715651HCID 131715651, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

N-methyl-BOC-2,6-dimethyltyrosyl-(D)-alanylphenylpropylamide (iso F) from Example 12 was treated with methanol-HCl/dioxane as described in Example 12, except that no methanol was used after the removal of methanol-HCl/dioxane, so no reduction of volume was necessary before lyophilization. The product is

Workup

  1. customafter the removal of methanol-HCl/dioxane

Sources & evidence

ORD record
ord-5a1ed69682d5438bb6eea563e91bc320
Source dataset
uspto-grants-1988_07
Patent number
US04760180

Reaction notes

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