Sodium Hydroxide → HCID 10431045, compound

HRID 845896Notes

Reaction equation

C([O:8][C:9](=[O:36])[C@H:10]([CH2:19][C:20]1[C:25]([CH3:26])=[CH:24][C:23]([O:27][CH2:28][C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)=[CH:22][C:21]=1[CH3:35])[NH:11][C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])C1C=CC=CC=1.[OH-].[Na+]>>[CH3:17][C:15]([CH3:18])([O:14][C:12]([NH:11][CH:10]([C:9]([OH:36])=[O:8])[CH2:19][C:20]1[C:25]([CH3:26])=[CH:24][C:23]([O:27][CH2:28][C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)=[CH:22][C:21]=1[CH3:35])=[O:13])[CH3:16]

Participants

Reactant 2

HCID 14798Sodium Hydroxide

HCID 70409453HCID 70409453, compound

Product 1

HCID 10431045HCID 10431045, compound

Procedure

O-benzyl-Boc-2,6-dimethyltyrosine benzyl ester, prepared as in Example 12 (5 g, 10.21 mmol), was treated with NaOH(3.27 g, 81.70 mmol), as described in Example 1, giving the title compound. NMR: benzyl methylene at ∫4.99s (2 protons). EXAMPLE 27

Sources & evidence

ORD record: ord-e9074f3f1a174193bc6b791b4630ef04
Source dataset: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04760180

Reaction notes

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