Methanol → HCID 10253045, compound

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Reaction Steps

The title compound of Example 54 (2.42 g) was dissolved in 5 ml of 1:1 CH2Cl2 : methanol, and added to methanolic NaOH (1N, 100 ml). After 3 hr of stirring, the mixture was concentrated to 75 ml, diluted to 500 ml with water, and extracted twice with ether to remove non-acidic contaminants. The aqueous phase was made acidic with 0.5N KHSO4, and then extracted four times with CH2Cl2. The CH2Cl2 fractions were combined, dried (MgSO4), filtered, and stripped to give the title compound (1.75 g). NMR:α methyl group at ∫2.75.

Provenance & Evidence