Sodium → isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate

Participants

Role	Name	HCID	Charge
Reactant	Sodium	HCID 5360545	—
Reactant	HCID 20130707	HCID 20130707	—
Solvent	Isopropanol dimethylformamide	HCID 20197112	—
Product	isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate	HCID 20130696	—

Reaction Steps

using isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate with sodium isopropylate in an isopropanol/dimethylformamide mixture there is obtained isopropyl 2-chloro-4-fluoro-5-{1,4,6,7-tetrahydro-2,4-dioxo-thieno[3,2-d]pyrimidin-3(2H)-yl}-benzoate, m.p. 252°-254° C.,

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US04760163
Source dataset	uspto-grants-1988_07
ORD ID	ord-8e92ea448d9741299244b4c86f4b1d83
Source note	uspto-grants-1988_07