Ammonia → HCID 86742801, compound

HRID 845922Notes

Reaction equation

HRID 845922 reaction equation
[NH3:1].O=[C:3]([C:11]([F:14])([F:13])[F:12])[CH:4]([F:10])[C:5]([O:7][CH2:8][CH3:9])=[O:6].O>C1(C)C=CC=CC=1>[NH2:1]/[C:3](/[C:11]([F:14])([F:13])[F:12])=[C:4](/[F:10])\[C:5]([O:7][CH2:8][CH3:9])=[O:6]

Participants

5

Reactant 3

HCID 222AmmoniaHCID 962WaterHCID 10954607Ethyl 2,4,4,4-tetrafluoro-3-oxobutanoate

Product 1

HCID 86742801HCID 86742801, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ammonia is introduced with stirring into a solution of 7.5 g of ethyl 3-oxo-2,4,4,4-tetrafluorobutyrate in 20 ml of toluene at 75° C. up to saturation. Then the reaction mixture is heated using a water separator for 5 hours, during which ethyl 3-amino-2,4,4,4-tetrafluorocrotonate is formed as an intermediate.

Workup

  1. temperatureThen the reaction mixture is heated
  2. customfor 5 hours

Sources & evidence

ORD record
ord-fa35baf7dbbb495da1ea7500ede8ebe5
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

Loading…