HCID 20130587, compound → HCID 20137731, compound

HRID 845963Notes

Reaction equation

HRID 845963 reaction equation
[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[C:16]3[CH2:19][CH2:20][CH2:21][C:15]=3[N:14]([CH3:22])[C:13]2=[O:23])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]>C(O)(C)(C)C>[Cl:1][C:2]1[CH:10]=[C:9]([F:11])[C:8]([N:12]2[C:17](=[O:18])[C:16]3[CH2:19][CH2:20][CH2:21][C:15]=3[N:14]([CH3:22])[C:13]2=[O:23])=[CH:7][C:3]=1[C:4]([O:6][C:3]([CH3:7])([CH3:4])[CH3:2])=[O:5]

Participants

3

Reactant 1

HCID 20130587HCID 20130587, compound

Product 1

HCID 20137731HCID 20137731, compound

Reagents, catalysts & solvents 1

HCID 6386tert-ButanolSolvent

Procedure

using 2-chloro-4-fluoro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3-yl)-benzoic acid via the corresponding acid chloride and tert.butanol there is obtained tert.butyl 2-chloro-4-fluoro-5-(1,2,4,5,6,7-hexahydro-1-methyl-2,4-dioxo-3H-cyclopenta[d]pyrimidin-3yl)-benzoate, 1H--NMR (CDCl3, 400 MHz) 7.76 ppm (d, 1H), 7.31 ppm (d, 1H), 3.41 ppm (s, 3H), 2.94 ppm (m, 2H), 2.81 ppm (m, 2H), 2.17 ppm (m 2H), 1.57 ppm (s, 9H).

Sources & evidence

ORD record
ord-ee6c04a9372d49c889a4859d919e418a
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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