Ethyl 2-oxocyclohexanecarboxylate → Ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)-1-cyclohexen-1-yl]ureido}-benzoate

HRID 845972Notes

Reaction equation

HRID 845972 reaction equation
[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH2:16])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:17][CH2:18][O:19][C:20]([CH:22]1[C:27](=O)[CH2:26][CH2:25][CH2:24][CH2:23]1)=[O:21]>>[Cl:1][C:2]1[CH:12]=[CH:11][C:10]([NH:13][C:14]([NH:16][C:23]2[CH2:24][CH2:25][CH2:26][CH2:27][C:22]=2[C:20]([O:19][CH2:18][CH3:17])=[O:21])=[O:15])=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 95543Ethyl 2-oxocyclohexanecarboxylateHCID 21270735Ethyl 2-chloro-5-ureidobenzoate

Product 1

HCID 20130639Ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)-1-cyclohexen-1-yl]ureido}-benzoate

Procedure

using ethyl 2-chloro-5-ureidobenzoate and ethyl cyclohexanone-2-carboxylate there is obtained ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)-1-cyclohexen-1-yl]ureido}-benzoate, m.p. 119°-122° C.,

Sources & evidence

ORD record
ord-0526bf5ecbec48e5b118c8f3329a49d3
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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