Ethyl 2-oxocyclohexanecarboxylate → HCID 20130701, compound

HRID 845974Notes

Reaction equation

HRID 845974 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH2:18])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH3:19][CH2:20][O:21][C:22]([CH:24]1[C:29](=O)[CH2:28][CH2:27][CH2:26][CH2:25]1)=[O:23]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:25]2[CH2:26][CH2:27][CH2:28][CH2:29][C:24]=2[C:22]([O:21][CH2:20][CH3:19])=[O:23])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 95543Ethyl 2-oxocyclohexanecarboxylateHCID 20130672Isopropyl 2-chloro-4-fluoro-5-ureidobenzoate

Product 1

HCID 20130701HCID 20130701, compound

Procedure

using isopropyl 2-chloro-4-fluoro-5-ureidobenzoate and ethyl cyclohexanone-2-carboxylate there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-cyclohexen-1-yl]ureido}-benzoate, m.p. 129°-130° C.,

Sources & evidence

ORD record
ord-11f7c42200b04979b5e53ff9a3b58bdc
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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