2-Thiophenecarboxylic acid, tetrahydro-3-oxo-, methyl ester → Isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate

HRID 845976Notes

Reaction equation

HRID 845976 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH2:18])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].O=[C:20]1[CH2:24][CH2:23][S:22][CH:21]1[C:25]([O:27][CH3:28])=[O:26]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:20]2[CH2:24][CH2:23][S:22][C:21]=2[C:25]([O:27][CH3:28])=[O:26])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 1028702-Thiophenecarboxylic acid, tetrahydro-3-oxo-, methyl esterHCID 20130672Isopropyl 2-chloro-4-fluoro-5-ureidobenzoate

Product 1

HCID 20130707Isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate

Procedure

using isopropyl 2-chloro-4-fluoro-5-ureidobenzoate and methyl 3-oxotetrahydrothiophene-2-carboxylate there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(methoxycarbonyl)-4,5-dihydro-thien-3-yl]ureido}-benzoate, m.p. 161°-163° C.,

Sources & evidence

ORD record
ord-0928b37009ad47b89504e690953f28de
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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