Ethyl 3-oxovalerate → HCID 53806823, compound

HRID 845980Notes

Reaction equation

HRID 845980 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH2:18])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH3:19][CH2:20][C:21]([CH2:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=O>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:21]([CH2:20][CH3:19])=[CH:23][C:24]([O:26][CH2:27][CH3:28])=[O:25])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

3

Reactant 2

HCID 78656Ethyl 3-oxovalerateHCID 20130672Isopropyl 2-chloro-4-fluoro-5-ureidobenzoate

Product 1

HCID 53806823HCID 53806823, compound

Procedure

using isopropyl 2-chloro-4-fluoro-5-ureidobenzoate and ethyl 3-oxo-n-valerate and finely powdered Amberlyst®-15 (an organic polymeric resin featuring free sulphone groups) as catalyst there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-ethylvinyl]ureido}-benzoate, m.p. 123°-126° C.,

Sources & evidence

ORD record
ord-94ad4f137e4c4371b87e1886922d2663
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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