Ethyl 2-oxocyclopentanecarboxylate → HCID 20130684, compound

HRID 845984Notes

Reaction equation

HRID 845984 reaction equation
[Br:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH2:18])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH3:19][CH2:20][O:21][C:22]([CH:24]1[C:28](=O)[CH2:27][CH2:26][CH2:25]1)=[O:23]>C1(C)C=CC=CC=1>[Br:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:25]2[CH2:26][CH2:27][CH2:28][C:24]=2[C:22]([O:21][CH2:20][CH3:19])=[O:23])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5]

Participants

4

Reactant 2

HCID 69136Ethyl 2-oxocyclopentanecarboxylateHCID 20130643HCID 20130643, compound

Product 1

HCID 20130684HCID 20130684, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

using isopropyl 2-bromo-4-fluoro-5-ureidobenzoate and ethyl cyclopentanone-2-carboxylate in toluene there is obtained isopropyl 2-bromo-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-cyclopenten-1-yl]ureido}-benzoate, m.p. 150°-154° C.,

Sources & evidence

ORD record
ord-16fa4342a7e2435cb5a86dd36bd3d050
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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