Ethyl 2-oxocyclopentanecarboxylate → HCID 20130705, compound

HRID 845985Notes

Reaction equation

HRID 845985 reaction equation
[Br:1][C:2]1[C:13]([NH:14][C:15]([NH2:17])=[O:16])=[CH:12][C:5]([C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7])=[C:4]([F:18])[CH:3]=1.[CH3:19][CH2:20][O:21][C:22]([CH:24]1[C:28](=O)[CH2:27][CH2:26][CH2:25]1)=[O:23]>C1(C)C=CC=CC=1>[Br:1][C:2]1[C:13]([NH:14][C:15]([NH:17][C:25]2[CH2:26][CH2:27][CH2:28][C:24]=2[C:22]([O:21][CH2:20][CH3:19])=[O:23])=[O:16])=[CH:12][C:5]([C:6]([O:8][CH:9]([CH3:11])[CH3:10])=[O:7])=[C:4]([F:18])[CH:3]=1

Participants

4

Reactant 2

HCID 69136Ethyl 2-oxocyclopentanecarboxylateHCID 20130693HCID 20130693, compound

Product 1

HCID 20130705HCID 20130705, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

using isopropyl 4-bromo-2-fluoro-5-ureidobenzoate and ethyl cyclopentanon-2-carboxylate is toluene there is obtained isopropyl 4-bromo-2-fluoro-5-{3-[2-(ethoxycarbonyl)-1-cyclopenten-1-yl]ureido}-benzoate, m.p. 166°-168° C.

Sources & evidence

ORD record
ord-a71462df0cab4aa3bad93de24aa83711
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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