Isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate → HCID 54323609, compound

HRID 845990Notes

Reaction equation

HRID 845990 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]=[C:16]=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[NH2:18]/[C:19](/[CH3:27])=[C:20](/[F:26])\[C:21]([O:23][CH2:24][CH3:25])=[O:22]>>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([NH:15][C:16]([NH:18][C:19]([CH3:27])=[C:20]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[F:26])=[O:17])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

3

Reactant 2

HCID 13519895Isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoateHCID 55288618HCID 55288618, compound

Product 1

HCID 54323609HCID 54323609, compound

Procedure

using isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate and ethyl 3-amino-2-fluorocrotonate there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-2-fluoro-1-methylvinyl]ureido}-benzoate, m.p. 150°-152° C.,

Sources & evidence

ORD record
ord-b953a1394a87490dac17cf58e0dfce67
Source dataset
uspto-grants-1988_07
Patent number
US04760163

Reaction notes

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