HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 3-amino-2-ethylcrotonate → Isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methyl-1-butenyl]ureido}-benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 3-amino-2-ethylcrotonate | HCID 10630766 | — |
| Reactant | Isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate | HCID 13519895 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | Isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methyl-1-butenyl]ureido}-benzoate | HCID 54032414 | — |
Reaction Steps
using isopropyl 2-chloro-4-fluoro-5-isocyanatobenzoate and ethyl 3-amino-2-ethylcrotonate in dimethylformamide there is obtained isopropyl 2-chloro-4-fluoro-5-{3-[2-(ethoxycarbonyl)-1-methyl-1-butenyl]ureido}-benzoate, m.p. 112°-115° C.,
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04760163 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-947ed14d3eb9463e989bf8ad319d13c5 |
| Source note | uspto-grants-1988_07 |