反应详情

Ethoxyamine hydrochloride (0.45 g) and then aqueous 1% sodium hydroxide (18.4 ml) were added to a solution of 3-hydroxy-5-mesityl-2-propionylcyclohex-2-en-1-one (1.2 g; 4.2 mmole) in anhydrous absolute ethanol (200 ml). The mixture was stirred at room temperature for a period of 4 hours and then the ethanol was removed by evaporation under reduced pressure using a rotary evaporator. The residue was treated with dichloromethane and the organic phase was washed twice with dilute aqueous hydrochloric acid and twice with water. The organic phase was dried over anhydrous sodium sulfate and the solvent was removed by evaporation under reduced pressure to give the product, 2-[1-(ethoxyimino)propyl]-3-hydroxy-5-mesitylcyclohex-2-en-1-one (1.25 g; 93%), as a pale yellow oil.

1. customthe ethanol was removed by evaporation under reduced pressure
2. customa rotary evaporator
3. additionThe residue was treated with dichloromethane
4. washthe organic phase was washed twice with dilute aqueous hydrochloric acid and twice with water
5. dry with materialThe organic phase was dried over anhydrous sodium sulfate
6. customthe solvent was removed by evaporation under reduced pressure