1H-Purine-8-butanoic acid, 2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo- (9CI) → HCID 71771436, compound

HRID 846011Notes

Reaction equation

HRID 846011 reaction equation
[N:1]1([C:12](=[O:13])[C:11]2[NH:10][C:9]([CH2:14][CH2:15][CH2:16][C:17]([OH:19])=O)=[N:8][C:7]=2[N:5]([CH3:6])[C:3]1=[O:4])[CH3:2]>C(OC(=O)C)(=O)C>[CH3:6][N:5]1[C:3](=[O:4])[N:1]([CH3:2])[C:12](=[O:13])[C:11]2[N:10]3[C:17](=[O:19])[CH2:16][CH2:15][CH2:14][C:9]3=[N:8][C:7]1=2

Participants

3

Reactant 1

HCID 950361H-Purine-8-butanoic acid, 2,3,6,7-tetrahydro-1,3-dimethyl-2,6-dioxo- (9CI)2×

Product 1

HCID 71771436HCID 71771436, compound

Reagents, catalysts & solvents 1

HCID 7918Acetic AnhydrideSolvent

Procedure

Theophylline-8-butyric acid, 24g (example 1), was dissolved in 500 ml of acetic anhydride with heating. The mixture was gently refluxed for 30 minutes, then filtered through a preheated funnel to remove insoluble material. The product crystallized upon cooling. The product was collected, washed with ether and hexane then dried in vacuum at 50° C. to give 20 g of theophylline-8-butyric acid lactam.

Workup

  1. temperaturewith heating
  2. temperatureThe mixture was gently refluxed for 30 minutes
  3. filtrationfiltered through a preheated funnel
  4. customto remove insoluble material
  5. customThe product crystallized
  6. temperatureupon cooling
  7. customThe product was collected
  8. washwashed with ether and hexane
  9. customthen dried in vacuum at 50° C.

Sources & evidence

ORD record
ord-43abf47695924a94931eb3af3c013e92
Source dataset
uspto-grants-1988_07
Patent number
US04760142

Reaction notes

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