反应详情

温度

85 °C

A mixture of N-(2-chlorophenyl)-4,5-dihydropyrido[4,3-b]thieno[2,3-d]oxepine-2-carbohydrazonamide (44 mg, 0.12 mmol) and 3 ml of triethylorthoformate was heated at 85° C. for 4 hours. The mixture was concentrated in vacuum and triturated with diethylether. The precipitate was collected, washed with diethylether and purified by flash chromatography eluting with 60% of ethyl acetate in hexane to give 320 (17 mg, 38%). MS: (ESI+) 381.1

1. concentrationThe mixture was concentrated in vacuum
2. customtriturated with diethylether
3. customThe precipitate was collected
4. washwashed with diethylether
5. custompurified by flash chromatography
6. washeluting with 60% of ethyl acetate in hexane