反应详情

14.2 g (49.4 mmol) of 6-(3-amino-4-acetylaminoethylaminophenyl)-3(2H)-pyridazinone are refluxed for one hour in 60 ml of formic acid. Then the excess formic acid is distilled off in vacuo, the residue is mixed with 50 ml of ice water and then adjusted to pH 8-9 with concentrated ammonia solution. The product precipitated is suction filtered, washed with about 50 ml of cold water, then with 50 ml of ether and dried.

1. distillationThen the excess formic acid is distilled off in vacuo
2. additionthe residue is mixed with 50 ml of ice water
3. customThe product precipitated
4. filtrationfiltered
5. washwashed with about 50 ml of cold water
6. dry with materialwith 50 ml of ether and dried