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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846108Generated: November 1, 2026

6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone → 6-[4-[3-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

https://huagongshe.com/reaction/846108

Reaction equation

Participants

RoleNameHCIDCharge
Reactant6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 15016365—
Reactant2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxiraneHCID 15107805—
Product6-[4-[3-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 14884420—

Reaction Steps

Prepared analogously to Example 1 from 1-[4-(2-cyclobutylmethoxy-ethyl)phenoxy]-2,3-epoxypropane and 6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05135932
Source datasetuspto-grants-1992_08
ORD IDord-3ce3136d8c3544f48673191cdf32fb8b
Source noteuspto-grants-1992_08