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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846109Generated: November 4, 2026

2-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxirane → 6-[4-[3-[3-(4-(2-Cyclopropylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

https://huagongshe.com/reaction/846109

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxiraneHCID 11791542—
Reactant6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 15016365—
Product6-[4-[3-[3-(4-(2-Cyclopropylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]propoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 14884421—

Reaction Steps

Prepared analogously to Example 1 from 1-[4-(2-cyclopropylmethoxyethyl)phenoxy]-2,3-epoxypropane and 6-[4-(3-aminopropoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05135932
Source datasetuspto-grants-1992_08
ORD IDord-1891595bd818434bb8be4ef6f54602c6
Source noteuspto-grants-1992_08