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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846111Generated: October 31, 2026

2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane → 6-[4-[2-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

https://huagongshe.com/reaction/846111

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxiraneHCID 15107805—
Reactant6-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 15107822—
Product6-[4-[2-[3-(4-(2-Cyclobutylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 14884423—

Reaction Steps

Prepared analogously to Example 1 from 1-[4-(2-cyclobutylmethoxyethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05135932
Source datasetuspto-grants-1992_08
ORD IDord-d876c1d0ee734bfdad9cb45f28e71781
Source noteuspto-grants-1992_08