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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846113Generated: October 29, 2026

2-((4-((2-(1-Methylethoxy)ethoxy)methyl)phenoxy)methyl)oxirane → 6-[4-[2-[3-(4-(2-Isopropoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

https://huagongshe.com/reaction/846113

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-((4-((2-(1-Methylethoxy)ethoxy)methyl)phenoxy)methyl)oxiraneHCID 15107809—
Reactant6-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 15107822—
Product6-[4-[2-[3-(4-(2-Isopropoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 14884425—

Reaction Steps

Prepared analogously to Example 1 from 1-[4-(2-isopropoxyethoxymethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05135932
Source datasetuspto-grants-1992_08
ORD IDord-2b128b752bfc4a54a36fc886d0f368d4
Source noteuspto-grants-1992_08