2-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxirane → 6-[4-[2-[3-(4-(2-Cyclopropylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 846120Notes

Reaction equation

HRID 846120 reaction equation
[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][C:8]2[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]3[O:16][CH2:15]3)=[CH:10][CH:9]=2)[CH2:3][CH2:2]1.[NH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:28]=[CH:27][C:26]([C:29]2[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=2)=[CH:25][CH:24]=1>>[CH:1]1([CH2:4][O:5][CH2:6][CH2:7][C:8]2[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]([OH:16])[CH2:15][NH:19][CH2:20][CH2:21][O:22][C:23]3[CH:24]=[CH:25][C:26]([C:29]4[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=4)=[CH:27][CH:28]=3)=[CH:10][CH:9]=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 117915422-((4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)methyl)oxiraneHCID 144418666-[4-(2-aminoethoxy)-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 148844286-[4-[2-[3-(4-(2-Cyclopropylmethoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-cyclopropylmethoxy-ethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)-phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-a0a7402c577240b392fae355432f714a
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

Loading…