1-[4-(2-Isobutoxyethyl)phenoxy]-2,3-epoxypropane → 6-[3-[2-[3-(4-(2-Isobutoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 846127Notes

Reaction equation

HRID 846127 reaction equation
[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]2[O:16][CH2:15]2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3].[NH2:19][CH2:20][CH2:21][O:22][C:23]1[CH:24]=[C:25]([C:29]2[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=2)[CH:26]=[CH:27][CH:28]=1>>[CH2:1]([O:5][CH2:6][CH2:7][C:8]1[CH:18]=[CH:17][C:11]([O:12][CH2:13][CH:14]([OH:16])[CH2:15][NH:19][CH2:20][CH2:21][O:22][C:23]2[CH:24]=[C:25]([C:29]3[CH2:30][CH2:31][C:32](=[O:35])[NH:33][N:34]=3)[CH:26]=[CH:27][CH:28]=2)=[CH:10][CH:9]=1)[CH:2]([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 151078061-[4-(2-Isobutoxyethyl)phenoxy]-2,3-epoxypropaneHCID 198846776-[3-(2-aminoethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 148844316-[3-[2-[3-(4-(2-Isobutoxy-ethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-isobutoxy-ethyl)phenoxy]-2,3-epoxypropane and 6-[3-(2-aminoethoxy)phenyl]-4,5-dihydro-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-38441cbfcb1842c88beeabcbb827a6b9
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

Loading…