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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846133Generated: October 31, 2026

2-[(2-Chloro-5-methylphenoxy)methyl]oxirane → 6-[2-[2-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone

https://huagongshe.com/reaction/846133

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-[(2-Chloro-5-methylphenoxy)methyl]oxiraneHCID 13012836—
Reactant6-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinoneHCID 15107841—
Product6-[2-[2-[3-(2-Chloro-5-methyl-phenoxy)-2-hydroxypropylamino]ethyl]benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinoneHCID 14884436—

Reaction Steps

Prepared analogously to Example 1 from 1-(2-chloro-5-methyl-phenoxy)-2,3-epoxypropane and 6-[2-(2-aminoethyl)benzimidazol-5-yl]-4,5-dihydro-3(2H)-pyridazinone.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05135932
Source datasetuspto-grants-1992_08
ORD IDord-e68aca5fef4b47888f019fe2e69d16ca
Source noteuspto-grants-1992_08