2-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxirane → 6-[3-[2-[3-(4-(2-Cyclobutylmethoxyethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-3(2H)-pyridazinone

HRID 846162Notes

Reaction equation

HRID 846162 reaction equation
[CH:1]1([CH2:5][O:6][CH2:7][CH2:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]3[O:17][CH2:16]3)=[CH:11][CH:10]=2)[CH2:4][CH2:3][CH2:2]1.[NH2:20][CH2:21][CH2:22][O:23][C:24]1[CH:25]=[C:26]([C:30]2[CH:31]=[CH:32][C:33](=[O:36])[NH:34][N:35]=2)[CH:27]=[CH:28][CH:29]=1>>[CH:1]1([CH2:5][O:6][CH2:7][CH2:8][C:9]2[CH:19]=[CH:18][C:12]([O:13][CH2:14][CH:15]([OH:17])[CH2:16][NH:20][CH2:21][CH2:22][O:23][C:24]3[CH:25]=[C:26]([C:30]4[CH:31]=[CH:32][C:33](=[O:36])[NH:34][N:35]=4)[CH:27]=[CH:28][CH:29]=3)=[CH:11][CH:10]=2)[CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 151078052-({4-[2-(Cyclobutylmethoxy)ethyl]phenoxy}methyl)oxiraneHCID 151078736-[3-(2-aminoethoxy)phenyl]-3(2H)-pyridazinone

Product 1

HCID 148844126-[3-[2-[3-(4-(2-Cyclobutylmethoxyethyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-cyclobutylmethoxyethyl)phenoxy]-2,3-epoxypropane and 6-[3-(2-aminoethoxy)phenyl]-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-4dc01f0a094a4811b740b27144667160
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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