1-[4-(2-Phenoxyethoxymethyl)phenoxy]-2,3-epoxypropane → 6-[4-[2-[3-(4-(2-Phenoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

HRID 846164Notes

Reaction equation

HRID 846164 reaction equation
[O:1]([CH2:8][CH2:9][O:10][CH2:11][C:12]1[CH:22]=[CH:21][C:15]([O:16][CH2:17][CH:18]2[O:20][CH2:19]2)=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([C:33]2[CH2:34][CH2:35][C:36](=[O:39])[NH:37][N:38]=2)=[CH:29][C:28]=1[Cl:40]>>[O:1]([CH2:8][CH2:9][O:10][CH2:11][C:12]1[CH:22]=[CH:21][C:15]([O:16][CH2:17][CH:18]([OH:20])[CH2:19][NH:23][CH2:24][CH2:25][O:26][C:27]2[CH:32]=[CH:31][C:30]([C:33]3[CH2:34][CH2:35][C:36](=[O:39])[NH:37][N:38]=3)=[CH:29][C:28]=2[Cl:40])=[CH:14][CH:13]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 151078101-[4-(2-Phenoxyethoxymethyl)phenoxy]-2,3-epoxypropaneHCID 151078226-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Product 1

HCID 151078756-[4-[2-[3-(4-(2-Phenoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-chloro-phenyl]-4,5-dihydro-3(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-phenoxyethoxymethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)-3-chloro-phenyl]-4,5-dihydro-3-(2H)-pyridazinone.

Sources & evidence

ORD record
ord-565ea1195cf3453f8a28e263c32efc41
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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