6-[4-(2-aminoethoxy)-phenyl]-4,5-dihydro-3(2H)-pyridazinone → 6-[4-[2-[3-(4-(2-n-Butyloxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3-(2H)-pyridazinone

HRID 846168Notes

Reaction equation

HRID 846168 reaction equation
[CH2:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][CH:16]2[O:18][CH2:17]2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH3:4].[NH2:21][CH2:22][CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([C:31]2[CH2:32][CH2:33][C:34](=[O:37])[NH:35][N:36]=2)=[CH:27][CH:26]=1>>[CH2:1]([O:5][CH2:6][CH2:7][O:8][CH2:9][C:10]1[CH:20]=[CH:19][C:13]([O:14][CH2:15][CH:16]([OH:18])[CH2:17][NH:21][CH2:22][CH2:23][O:24][C:25]2[CH:26]=[CH:27][C:28]([C:31]3[CH2:32][CH2:33][C:34](=[O:37])[NH:35][N:36]=3)=[CH:29][CH:30]=2)=[CH:12][CH:11]=1)[CH2:2][CH2:3][CH3:4]

Participants

3

Reactant 2

HCID 144418666-[4-(2-aminoethoxy)-phenyl]-4,5-dihydro-3(2H)-pyridazinoneHCID 151078111-[4-(2-n-Butyloxyethoxymethyl)phenoxy]-2,3-epoxypropane

Product 1

HCID 151078796-[4-[2-[3-(4-(2-n-Butyloxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]phenyl]-4,5-dihydro-3-(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-n-butyloxyethoxymethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)phenyl]-4,5-dihydro-3-(2H)-pyridazinone.

Sources & evidence

ORD record
ord-b36589362c914e74b81fd95b26684d58
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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