6-[4-(2-aminoethoxy)-3-methyl-phenyl]-3(2H)-pyridazinone → 6-[4-[2-[3-(4-(2-Methoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-methyl-phenyl]-3-(2H)-pyridazinone

HRID 846169Notes

Reaction equation

HRID 846169 reaction equation
[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]2[O:15][CH2:14]2)=[CH:9][CH:8]=1.[NH2:18][CH2:19][CH2:20][O:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:29]=[CH:30][C:31](=[O:34])[NH:32][N:33]=2)=[CH:24][C:23]=1[CH3:35]>>[CH3:1][O:2][CH2:3][CH2:4][O:5][CH2:6][C:7]1[CH:17]=[CH:16][C:10]([O:11][CH2:12][CH:13]([OH:15])[CH2:14][NH:18][CH2:19][CH2:20][O:21][C:22]2[CH:27]=[CH:26][C:25]([C:28]3[CH:29]=[CH:30][C:31](=[O:34])[NH:32][N:33]=3)=[CH:24][C:23]=2[CH3:35])=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 151078196-[4-(2-aminoethoxy)-3-methyl-phenyl]-3(2H)-pyridazinoneHCID 198846091-[4-(2-Methoxyethoxymethyl)phenoxy]-2,3-epoxypropane

Product 1

HCID 198846446-[4-[2-[3-(4-(2-Methoxyethoxy-methyl)phenoxy)-2-hydroxypropylamino]ethoxy]-3-methyl-phenyl]-3-(2H)-pyridazinone

Procedure

Prepared analogously to Example 1 from 1-[4-(2-methoxyethoxymethyl)phenoxy]-2,3-epoxypropane and 6-[4-(2-aminoethoxy)-3-methyl-phenyl]-3(2H)-pyridazinone.

Sources & evidence

ORD record
ord-14570bf38d654440bc222529c8c441ef
Source dataset
uspto-grants-1992_08
Patent number
US05135932

Reaction notes

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