Ammonia → HCID 14698599, compound

Participants

Reaction Steps

2 g. 4-(1-Cyano-1-methylethyl)-N-(4-methoxyphenyl)-benzamide (Example 22) in 100 ml. 10% ethanolic ammonia solution are hydrogenated in the presence of 1 g. 5% rhodium on aluminium oxide for 24 hours at 5 bar. The reaction mixture is filtered with suction, the filtrate is evaporated to dryness and the residue is recrystallised from ethanol. There is obtained 0.68 g. (34% of theory) of the title compound in the form of colourless crystals; m.p. 139°-140° C.

Provenance & Evidence