Hydrochloric Acid → HCID 19884827, compound

Participants

Reaction Steps

To a stirred solution of the compound from Step B (550 mg, 1.21 mmole) in THF (15 ml) was added 3 ml of 1N NaOH. The mixture was stirred at room temperature for 1.5 hours. The reaction mixture was diluted with H2O (50 ml) and acidified with concentrated HCl to pH=5. A white solid formed which was extracted with methylene chloride (2×). The combined organic extracts were washed with brine, dried (MgSO4) and concentrated in vacuo to yield the title compound as a white solid, m.p. 136°-137°.

Provenance & Evidence