Methyl Ethyl Ketone → HCID 54148028, compound

HRID 846256Notes

Reaction equation

HRID 846256 reaction equation
[CH2:1]([O:8][C:9]1[CH:16]=[CH:15][C:12]([CH:13]=O)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:17][C:18]([CH2:20][CH3:21])=[O:19].[OH-].[Na+]>CO>[C:2]1([CH2:1][O:8][C:9]2[CH:16]=[CH:15][C:12]([CH:13]=[CH:17][C:18](=[O:19])[CH2:20][CH3:21])=[CH:11][CH:10]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

5

Reactant 3

HCID 6569Methyl Ethyl KetoneHCID 14798Sodium Hydroxide2×HCID 78109Benzaldehyde, 4-(phenylmethoxy)-

Product 1

HCID 54148028HCID 54148028, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

4-Benzyloxybenzaldehyde (100 g) and 43.2 g of methylethyl ketone were added to 1.2 1 of methanol and stirred at 15°-20° C. during which 125 ml of sodium hydroxide (50%) was added dropwise. Following completion of the addition of sodium hydroxide, the mixture was stirred at room temperature for about 8 hours. The resultant solid was collected and washed with water and recrystallized from acetone to yield the desired subtitled intermediate, m.p. 123°-125° C.

Workup

  1. additionwas added dropwise
  2. customThe resultant solid was collected
  3. washwashed with water
  4. customrecrystallized from acetone

Sources & evidence

ORD record
ord-be82747317754fc59249d3e86dc10550
Source dataset
uspto-grants-1992_08
Patent number
US05135955

Reaction notes

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