Dimethylformamide → 2,4-Dimethylthiazole-5-carbonyl chloride

HRID 846290Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 846290
[CH3:1][C:2]1[S:3][C:4]([C:8]([OH:10])=O)=[C:5]([CH3:7])[N:6]=1.CN(C)C=O.C(Cl)([Cl:18])=O>C1(C)C=CC=CC=1>[CH3:1][C:2]1[S:3][C:4]([C:8]([Cl:18])=[O:10])=[C:5]([CH3:7])[N:6]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 6371PhosgeneHCID 736488Dimethyl-1,3-thiazole-5-carboxylic acid

Produkt 1

HCID 146531402,4-Dimethylthiazole-5-carbonyl chloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

In a similar apparatus to Example 1, 15.7 g (0.1 mole) of 2,4-dimethylthiazole-5-carboxylic acid were suspended in 100 ml of toluene, followed by the addition of 0.1 g of N,N-dimethylformamide. Under heating and reflux, phosgene was blown at a rate of 1.3 l/hr for 5 hours (0.29 mole). After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 17.2 g of 2,4-dimethylthiazole-5-carboxylic acid chloride. Its purity and yield were 97.5% and 98.0%, respectively.

Aufarbeitung

  1. temperatureUnder heating
  2. temperaturereflux
  3. customAfter completion of the reaction
  4. filtrationthe reaction mixture was filtered
  5. concentrationthe filtrate was concentrated

Quellen und Nachweise

ORD-Eintrag
ord-ae8c2d3e2efb4f7da00d3a41a0ba9b95
Quelldatensatz
uspto-grants-1992_08
Patentnummer
US05136042

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