Dimethylformamide → HCID 14716208, compound

Participants

Reaction Steps

In a 200-ml three-neck flask, 15.0 g (0.08 mole) of 2-propyl-4-methylthiazole-5-carboxylic acid were suspended in 100 ml of xylene, followed by the addition of 0.05 g of N,N-dimethylformamide. Under heating and reflux, phosgene was blown at a flow rate of 1.5 l/hr for 3 hours (0.20 mole). After completion of the reaction, the reaction mixture was filtered and the filtrate was concentrated to obtain 16.2 g of 2-propyl-4 -methylthiazole-5-carboxylic acid chloride. Its purity and yield were 97.3% and 98.2%, respectively.

Provenance & Evidence