反应详情

In a similar apparatus to Example 1, 15.7 g (0.1 mole) of 2,4-dimethylthiazole-5carboxylic acid were suspended in 100 ml of toluene. Under heating and reflux, phosgene was blown at a rate of 1.3 l/hr for 5 hours (0.29 mole). After completion of the reaction, the residue was filtered off and the filtrate was concentrated. As a result, 7.2 g of 2,4-dimethyl-thiazole-5-carboxylic acid chloride were obtained. Its purity and yield were 96.9% an 41.0%, respectively.

1. temperatureUnder heating
2. temperaturereflux
3. customAfter completion of the reaction
4. filtrationthe residue was filtered off
5. concentrationthe filtrate was concentrated