HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triphenylphosphine → Diethyl (7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine-4-yl)methylenemalonate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triphenylphosphine | HCID 11776 | — |
| Reactant | ethyl N-ethoxycarbonyliminocarbamate | HCID 220568 | — |
| Reactant | 2,3-Difluoro-6-(2,2-diethoxycarbonylethenyl)amino-[(2-hydroxypropyl)oxy]benzene | HCID 14697183 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | Diethyl (7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazine-4-yl)methylenemalonate | HCID 13364401 | — |
Reaction Steps
To a solution of 341 mg of triphenylphosphine in 5 ml of anhydrous tetrahydrofuran was added dropwise 226 mg of diethyl azodicarboxylate and the mixture was stirred under cooling with ice for 20 minutes. To this solution was added a solution of 373 mg of the compound obtained in Example 3 in 3 ml of anhydrous tetrahydrofuran, and the mixture was stirred at room temperature overnight.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05136059 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-e70bf8acb0d14364a763a85e765857dc |
| Source note | uspto-grants-1992_08 |