反应详情

To a solution of 7-bromo-3,4-dihydro-2H-benzo[b]oxepin-5-one (700 mg) in diethyl ether (20 mL) at 0° C. was added bromine (0.14 mL) dropwise and the reaction was stirred at room temperature for 16 h. The reaction was then quenched with aqueous sodium thiosulfate solution (30 mL) and the product extracted into diethyl ether (2×30 mL). The combined organics were dried (MgSO4), reduced in vacuo and purified on silica to give 4,7-dibromo-3,4-dihydro-2H-benzo[b]oxepin-5-one.

1. customThe reaction was then quenched with aqueous sodium thiosulfate solution (30 mL)
2. extractionthe product extracted into diethyl ether (2×30 mL)
3. dry with materialThe combined organics were dried (MgSO4)
4. custompurified on silica