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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846373Generated: November 2, 2026

(3,4-Dichlorophenyl)acetonitrile → 2,4-Diamino-5-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidine

https://huagongshe.com/reaction/846373

Reaction equation

Participants

RoleNameHCIDCharge
Reactant(3,4-Dichlorophenyl)acetonitrileHCID 76690—
Reactant2,4-Diamino-5-(2,3,5-trichlorophenyl)-6-trifluoromethylpyrimidineHCID 11772723—
SolventChloroform methanolHCID 21584188—
Product2,4-Diamino-5-(3,4-dichlorophenyl)-6-trifluoromethylpyrimidineHCID 19705114—

Reaction Steps

This compound was made in an analogous manner to the compound of Example 4, from 3,4-dichlorophenylacetonitrile (Aldrich) mp. 252°-254.5° C.: TLC (SiO2 ; methanol/chloroform, 1:9) Rf=0.38.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05136080
Source datasetuspto-grants-1992_08
ORD IDord-243be6668f1c4732a0bafd19e19aabaf
Source noteuspto-grants-1992_08