HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 846439Erstellt: 26. Oktober 2026
Sodium Iodide → 3-(4-(1-[1-Phenyl-1H-indol-3-yl]-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone dihydrochloride
https://huagongshe.com/reaction/846439
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Sodium Iodide | HCID 5238 | — |
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | 3-(4-Bromobutyl)-2,5,5-trimethyl-4-thiazolidinone | HCID 10779094 | — |
| Edukt | 1-(1-phenyl-1H-indol-3-yl)piperazine dihydrochloride | HCID 21706602 | — |
| Lösungsmittel | Acetonitrile | HCID 6342 | — |
| Produkt | 3-(4-(1-[1-Phenyl-1H-indol-3-yl]-4-piperazinyl)butyl)-2,5,5-trimethyl-4-thiazolidinone dihydrochloride | HCID 14856160 | 45,8% |
Reaktionsschritte
A mixture of 3-(4-bromobutyl)-2,5,5-trimethyl-4-thiazolidinone (5.00 g), 1-(1-phenyl-1H-indol-3-yl)piperazine dihydrochloride (7.80 g), N,N-diisopropylethylamine (9.65 g), NaI (350 mg) in acetonitrile (250 ml) was heated at 75° C. for 17 hours and the product was processed in substantially the same manner as in Example 10 to afford 2.80 g of crystals, m.p. 217°-219° C.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05136037 |
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| Quelldatensatz | uspto-grants-1992_08 |
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| ORD ID | ord-c8c564463b0940d9a655afd7dcf14595 |
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| Quellennotiz | uspto-grants-1992_08 |
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