HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 846445Generated: October 27, 2026
Sodium Iodide → 3-(4-(1-[1,2-Benzisothiazol-3-yl]-4-piperazinyl)butyl)1-thia-3-azaspiro[4.5]decan-4-one
https://huagongshe.com/reaction/846445
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Iodide | HCID 5238 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 3-(4-Bromobutyl)-1-thia-3-azaspiro[4.4]nonan-4-one | HCID 10708747 | — |
| Reactant | 3-(1-Piperazinyl)-1,2-benzisothiazole monohydrochloride | HCID 11521711 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 3-(4-(1-[1,2-Benzisothiazol-3-yl]-4-piperazinyl)butyl)1-thia-3-azaspiro[4.5]decan-4-one | HCID 10646968 | 49.5% |
Reaction Steps
A mixture of 3-(4-bromobutyl)-1-thia-3-azaspiro[4.4]nonan-4-one (4.00 g), 1-(1,2-benzisothiazol-3-yl)piperazine hydrochloride (3.67 g), K2CO3 (7.00 g) and NaI (300 mg) in acetonitrile (220 ml) was heated at 70° C. for 20 hours and the product was processed in substantially the same manner as in Example 10 to afford 3.01 g of crystalline solid, m.p. 209° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05136037 |
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| Source dataset | uspto-grants-1992_08 |
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| ORD ID | ord-79f9369865c34b3fa567fa6e7470d9c4 |
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| Source note | uspto-grants-1992_08 |
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