Methyl iodide → HCID 54176818, compound

Participants

Reaction Steps

To 5 ml of a DMF solution containing 200 mg (0.5181 mmol) of 2,2'-dihydroxy-5,5'-bis (3-methoxycarbonylpropyl) biphenyl and 0.329 ml (5.181 mmol) of methyl iodide, there were added 85.5 mg (0.6217 mmol) of anhydrous potassium carbonate and a small amount of copper powder and the resulting mixture was agitated for 4 hours at room temperature. The reaction mixture was filtered by suction through Celite to remove the solid matter and the filtrate was washed with ethyl acetate. After the solvent in the filtrate was evaporated off under reduced pressure, the evaporated residue was dissolved in chloroform. This solution was washed with dilute hydrochloric acid, dilute aqueous sodium bicarbonate, water and aqueous adding anhydrous sodium sulfate. The residue obtained after the solvent had been evaporated off was purified by silica gel column chromatography (with 20 g of WAKO-gel C-200, eluent: toluene and toluene/ethyl acetate of 50/1 and 25/1) to obtain 159 mg (0.3975 mmol, 77%) of 2-methoxy-2'-hydroxy-5,5 '-bis (3-methoxycarbonylpropyl) biphenyl as an oily product. 1H-NMR (CDCl3) δ (ppm): 1.96 (4H, m, 2CH2), 2.35 (2H, t, CH2), 2.36 (2H, t, CH2), 2.63 (2H, t, CH2), 2.66 (2H, t, CH2), 3.66 (6H, s, 2CH3), 3.87 (3H, s, CH3), 6.24 (1H, s, OH), 6.9-7.3 (6H, m, arom-H) MS (FAB): 400 (M+)

Provenance & Evidence