HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl iodide → N-(2,4-Dichloro-5-methoxyphenyl)acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | N-(2,4-Dichloro-5-hydroxyphenyl)acetamide | HCID 2735988 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | N-(2,4-Dichloro-5-methoxyphenyl)acetamide | HCID 14593783 | 99.9% |
Reaction Steps
A stirred mixture of 35.0 g (0.16 mole) of 2,4-dichloro-5-hydroxyacetanilide, 33.1 g (0.24 mole) of potassium carbonate, and 34.1 g (0.24 mole) of methyl iodide in 300 mL of acetone was heated at reflux for approximately 18 hours. The mixture was cooled and filtered. The filtrate was evaporated under reduced pressure to leave 37.4 g of 2,4-dichloro-5-methoxyacetanilide as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05136868 |
| Source dataset | uspto-grants-1992_08 |
| ORD ID | ord-f2c8ea1609384ea7857ec011af102844 |
| Source note | uspto-grants-1992_08 |