反应详情

A solution of 12.84 g (0.195 mole) of potassium hydroxide in 200 mL of water was added to a vigorously stirred solution of 34.0 g (0.097 mole) of 2-chloro-4-fluoro-5-nitrophenyl 4-methyl-3-nitrophenylsulfonate in 190 mL of p-dioxane. The resultant mixture was stirred at room temperature for approximately 18 hours. The reaction mixture was filtered and the filtrate acidified with concentrated hydrochloric acid. The acidic solution was extracted with diethyl ether. The ether extract was dried over anhydrous sodium sulfate, filtered, and the solvent evaporated under reduced pressure to leave a solid. The solid was washed with petroleum ether to yield 15.07 g of 2-chloro-4-fluoro-5-nitrophenol.

1. filtrationThe reaction mixture was filtered
2. extractionThe acidic solution was extracted with diethyl ether
3. extractionThe ether extract
4. dry with materialwas dried over anhydrous sodium sulfate
5. filtrationfiltered
6. customthe solvent evaporated under reduced pressure
7. customto leave a solid
8. washThe solid was washed with petroleum ether