反应详情

The reaction of 18.73 g (91.7 mmoles) of aluminum isopropoxide in 150 ml of toluene with 3.0 g (15.3 mmoles) of 6-(carbethoxymethyl)-3-methyl-2-cyclohexen-l-one was conducted in a similar manner to the synthesis of 3a,4,5,7a-tetrahydro-2(3H)-benzofuranone described in Example I. The crude material was purified by Kugelrohr distillation (bp 55°-80° C./0.0l mm Hg) to yield 1.7 g (74%) of cis 6-methyl-3a,4,5,7a-tetrahydro-2(3H)-benzofuranone, as confirmed by NMR and IR data.

1. distillationThe crude material was purified by Kugelrohr distillation (bp 55°-80° C./0.0l mm Hg)