Ammonia → 1,3-Bis[(2-hydroxyethyl)(4-nitrosophenyl)amino]-2-propanol

Participants

Reaction Steps

A solution of 1.14 moles (78.7 g) of sodium nitrite in 150 ml of water is added dropwise at between 0° C. and 5° C. to a solution of 0.5 mole (165.2 g) of N,N'-bis(β-hydroxyethyl)-N,N'-bis(phenyl)-1,3-diamino-2-propanol prepared in the preceding stage, 290 ml of concentrated hydrochloric acid and 900 g of ice. After the end of addition stirring is continued for 1 hour 30 minutes. The reaction medium is neutralized by adding 300 ml of 20% strength aqueous ammonia at 10° C. After filtering off, the product obtained is again made into a paste with water. It can be used wet for the following stage.

Provenance & Evidence