Thionyl Chloride → 3-(2-Thienyl)acryloylchloride

HRID 846546Notes

Reaction equation

HRID 846546 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([OH:10])=O.S(Cl)([Cl:13])=O>C1C=CC=CC=1>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=[CH:7][C:8]([Cl:13])=[O:10]

Participants

4

Reactant 2

HCID 24386Thionyl ChlorideHCID 928683-Thiophen-2-ylprop-2-enoic acid

Product 1

HCID 534112883-(2-Thienyl)acryloylchloride

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

65 ml of benzene was added to 10 grams of 3-(2-thienyl)acrylic acid. 7.8 ml of thionyl chloride was added dropwise slowly thereto at ambient temperature. The temperature was elevated to 70° C. and the heating was continued until foaming ceased. Benzene and thionyl chloride were distilled off and the residue was dried thoroughly under reduced pressure.

Workup

  1. customat ambient temperature
  2. customwas elevated to 70° C.
  3. distillationBenzene and thionyl chloride were distilled off
  4. customthe residue was dried thoroughly under reduced pressure

Sources & evidence

ORD record
ord-5b9c704ab78f493cb3353c14a2a222f9
Source dataset
uspto-grants-1992_08
Patent number
US05137638

Reaction notes

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