反应详情

Into a flask of 50 m were charged 1.84 g (7.4 mmol) of 4-(2-methyloctanoyl) anisole and 35 ml of dried toluene, to which was added 8.68 g of anhydrous aluminum bromide under ice cooling with stirring, and further the stirring was continued at room temperature over a night. Thereafter, the reaction mixture was stirred at 40° C. for 4 hours, cooled to room temperature and poured into 100 ml of ice water. After the extraction with 40 ml of toluene twice, the organic layer was washed with 80 ml of water, dried on magnesium sulfate, filtered, concentrated and distilled under a reduced pressure to obtain 1.70 g (7.3 mmol, yield 98%) of a redish brown and oily (+)-4-(2-methyloctanoyl) phenol.

1. waitfurther the stirring was continued at room temperature over a night
2. stirringThereafter, the reaction mixture was stirred at 40° C. for 4 hours
3. extractionAfter the extraction with 40 ml of toluene twice
4. washthe organic layer was washed with 80 ml of water
5. customdried on magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated
8. distillationdistilled under a reduced pressure