反应详情

Then, 2.38 g (19.0 mmol) of thionyl chloride was charged into a flask and maintained at a temperature of 36°~38° C., to which was added dropwise 2.15 g (15.9 mmol) of the above (+)-2-methyloctanoic acid in 7 minutes with stirring. The resulting mixture was stirred at room temperature for 40 minutes and at a temperature of 80° C. for 30 minutes. Then, the reaction product was distilled to obtain 2.81 g (15.9 mmol, yield 100%) of a colorless and transparent (+)-2-methyloctanoic acid chloride.

1. temperaturemaintained at a temperature of 36°~38° C., to which
2. stirringThe resulting mixture was stirred at room temperature for 40 minutes and at a temperature of 80° C. for 30 minutes
3. distillationThen, the reaction product was distilled