Ethanol → HCID 86746056, compound

HRID 846579Notes

Reaction equation

HRID 846579 reaction equation
C([OH:3])C.[OH-].[Na+:5].[OH:6][C:7]1[N:12]2[N:13]=[CH:14][C:15]([C:16]3[CH:21]=[CH:20][C:19]([S:22]([C:24]4[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=4)=[O:23])=[C:18]([O:30][CH3:31])[CH:17]=3)=[C:11]2[N:10]=[CH:9][N:8]=1>O>[OH2:3].[OH2:6].[CH3:31][O:30][C:18]1[CH:17]=[C:16]([C:15]2[CH:14]=[N:13][N:12]3[C:7]([O-:6])=[N:8][CH:9]=[N:10][C:11]=23)[CH:21]=[CH:20][C:19]=1[S:22]([C:24]1[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=1)=[O:23].[Na+:5]

Participants

5

Reactant 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 178487645HCID 178487645, compound

Product 1

HCID 86746056HCID 86746056, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

In a mixed solution prepared from 50 ml of ethanol, 10 ml of water and 145 mg of sodium hydroxide were dissolved 1.3 g of (-)-4-hydroxy-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine with stirring and the solvent was then distilled off under reduced pressure. After addition of 100 ml of ethyl acetate, the mixture was refluxed for 30 minutes. After cooling, the crystals were recovered by filtration and dried to give sodium (-)-8-(3-methoxy-4-phenylsulfinylphenyl)pyrazolo[1,5-a]-1,3,5-triazine-4-olate dihydrate.

Workup

  1. distillationthe solvent was then distilled off under reduced pressure
  2. additionAfter addition of 100 ml of ethyl acetate
  3. temperaturethe mixture was refluxed for 30 minutes
  4. temperatureAfter cooling
  5. filtrationthe crystals were recovered by filtration
  6. customdried

Sources & evidence

ORD record
ord-c87c1f97eb2a4e57a445523c28ae50c5
Source dataset
uspto-grants-1992_08
Patent number
US05137887

Reaction notes

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